Inhibition of Glioma Development by ASCL1-Mediated Direct Neuronal Reprogramming
نویسندگان
چکیده
منابع مشابه
Transient CREB-mediated transcription is key in direct neuronal reprogramming
Combinations of neuronal determinants and/or small-molecules such as Forskolin (Fk) can be used to convert different cell types into neurons. As Fk is known to activate cAMP-dependent pathways including CREB-activity, we aimed here to determine the role of CREB in reprogramming - including its temporal profile. We show that transient expression of the dominant-positive CREB-VP16 followed by its...
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ژورنال
عنوان ژورنال: Cells
سال: 2019
ISSN: 2073-4409
DOI: 10.3390/cells8060571